Israel and Gaza traded heavy fire on Friday but Egyptian mediators launched a new bid to end days of fighting that has killed dozens, all but one of them Palestinian.
The violence has been met with international calls for de-escalation, with the European Union pushing for an "immediate comprehensive ceasefire".
The Israeli army said it killed three leaders of the Islamic Jihad militant group Tuesday in air strikes on Gaza, which left a dozen dead according to the health ministry in the Hamas-controlled Palestinian territory.
The ministry said that women and children were among the dead, publishing a list of names without ages or detailing any affiliations.
Palestinian militants carried out a pair of attacks on Friday, killing three people and wounding at least seven as tensions soared after days of fighting at Jerusalem's most sensitive holy site. Earlier in the day, retaliatory Israeli airstrikes had hit Lebanon and the Gaza Strip, sparking fears of a broader conflict.
Israeli police stormed into the Al-Aqsa Mosque in Jerusalem's Old City early Wednesday, firing stun grenades at Palestinian youths who hurled firecrackers at them in a burst of violence during a sensitive holiday season. Palestinian militants in Gaza responded with rocket fire on southern Israel, prompting repeated Israeli airstrikes.