Novak was free in the first round, starting participation in the Masters in Italy on Tuesday.
Djokovic had two and a half weeks of rest, since he did not play at the Masters in Madrid after the ATP category 250 tournament in Belgrade.
His opponent is the 31st tennis player in the world, Taylor Fritz, with whom he has met three times so far.
Due to the fact that he defended the title, he remained at the same number of points, 12.030, and his advantage over second-placed Rafael Nadal is now 2.180 points.
Djokovic is getting closer to breaking Roger Federer's record of 310 weeks at the top of the ATP list, and that will officially happen on the list that will be published on March 8.