The latest attempt to repeal the Obama-era healthcare act has failed after a dramatic night in the US Senate, reported BBC.
At least three Republicans - John McCain, Susan Collins and Lisa Murkowski - voted against the bill, which needed a simple majority to pass.
President Donald Trump said the three had "let the American people down".
U.S. Senate Republicans narrowly agreed on July 25 to open debate on a bill to end Obamacare, but the party's seven-year effort to roll back Democratic President Barack Obama's signature healthcare law still faces significant hurdles.
The Senate deadlocked 50-50 on moving forward with the healthcare debate, forcing Vice President Mike Pence to cast the tie-breaking vote.
The US Senate voted 51-50 Tuesday to proceed with a debate on Republican plans to repeal Barack Obama's health care reforms, according to France24.
The vote was a victory for President Donald Trump, who spent weeks cajoling, strong-arming and warning Republicans to get on board with his effort to overhaul Obamacare.